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International Journal of Orthopaedics Sciences 2021; 7(2): 846-853:
– possesses potent antiinflammatory, analgesic & anti-arthritic activity
– its active constituent 3-O-Acetyl-11-keto-beta-boswellic acid (AKBA) inhibits 5-lipoxygenase and associated cellular inflammatory reactions, inhibits generation of pro-inflammatory cytokines which are involved in cartilage damage process.
– reduces MMP-9 & MMP-3 mRNA levels and MMP9 expression, decreases production of nitrite, prostaglandin E2 and cyclooxygenase-2.
– Boswellia showed efficacy against cancers, inflammatory diseases, wound healing etc.
Relieve joint pain and improve physical function (European Journal of Integrative Medicine Volume 40, December 2020)
International Journal of Orthopaedics Sciences 2021; 7(2): 846-853)
Curcumin exerts its anti-inflammatory action by interaction with NF-kB signaling pathway & reduces expression of inflammatory markers such as IL-1β, TNFalpha, COX-2 and MMP, upregulates the production of collagen-II and decreases MMP13 expression, thus inhibiting NF-kB pathway.
Curcumin also exert its anti-inflammatory and antioxidant effect by acting on pathways involving reactive oxygen species, Nrf2 and its target genes such as superoxide dismutase (SOD2), HO-1, and glutamate cysteine ligase catalytic subunit. It also promotes autophagy by attenuating Akt/mTOR pathway leading to reduced apoptosis and matrix degradation.
– Methionine is activated to S-adenosylmethionine (SAMe) in liver and kidney, SAMe has antioxidant properties and provides antioxidant enzyme glutathione peroxidase in the joints, inhibits the enzyme system which degrades cartilages thereby protects proteins and proteoglycans
– regulates cartilage regeneration by promoting anabolic process of cartilage
– Long-term use of SAMe have produced more prominent effect in OA patients then NSAIDs.
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